High pressure homogenizers for biotech/pharma
From lab to production scale
Avestin has a broad product portfolio. From 3 mL product sample to +500 l/hr.
Avestin has delivered more than 2000 homogenizers, and the world larges pharmecutical companies are among the customers.
Avestin is a manufacturer of high pressure homogenizers of the highest quality. Their equipment is used in a wide range of industries from dispersion of pigments to disruption of cells used for producing pharmaceutical products. Avestin is Canadian company with production and laboratory facilities in Ottawa.
Rupture of cells etc.
Homogenizers for cell cultivation laboratories and pilot plants
From Avestin we can offer homogenizers to be used primarily for research. These cover laboratory machines as well as homogenizers for pilot plants and small productions with capacities up to 1,000 l/h.
Test results obtained with the small laboratory models can be upscaled directly to the small production models.
Options for our homogenizers from Avestin include heat exchangers for temperature control and filters/extruders for liposomes.
Avestin’s unique high pressure homogenizers with adjustable homogenizing pressure from 35-2000 bar are extremely suitable for cell rupture (e.g. E. coli and yeast cells), dispersions, liposomes and various emulsions.
The high pressure homogenizers from Avestin can be delivered with either air-driven motors, where capacity depends on homogenizing pressure, or with electric motors, where capacity does not depend on homogenizing pressure.
Aseptic homogenizers with 6 zones:
- Homogenizer with four separate steam sterilizable zones, including product zone
- Possibility of monitoring inlet and outlet process temperature at each sterilized zone
High pressure homogenizers for production
Avestin’s standard programme includes 2 production homogenizers for max. 500 l/h and 1000 l/h respectively, but can also deliver customized machines for higher capacities.
The EmulsiFlex C500 and C1000 have electric gear motor-driven, triplex, high pressure pump designed to minimize the fluctuation of homogenizing pressure. There are no o-rings and gaskets in the high pressure product path. All face seals are precision-machined metal to metal or metal to ceramic. As for the laboratory models these are adjustable between 30 and 2000 bar.
The production machines are equipped with a dynamic homogenizing valve. The valve can be easily disassembled for cleaning or inspection. Submicron particles or droplets with diameters less than 50nm and extremely narrow size distributions can be achieved.
Both are available with sanitary and electropolished stainless steel heat exchangers to control inlet and outlet temperatures.
Avestin’s LiposoFast extruders are available in two versions:
- LiposoFast-Basic for either 0.25, 0.5 or 1.0 ml
- LiposoFast LF-50 for samples between 5 and 50 ml
Manual liposome extruders which extrude liposomes through a polycarbonate membrane of defined pore size by means of two small gas-tight syringes. The sample passes through the membrane by pressing the syringes back and forth. The syringes are available in 0.25, 0.5 and 1 ml.
Uses compressed air (up to 41 bar) to force the liposome sample through a polycarbonate membrane of defined pore size and can extrude samples between 5 and 50 ml. This extruder has a stainless steel sample cylinder with a heating jacket for heat-sensitive products. LiposoFast LF-50 is easy to clean and can be autoclaved.